DNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

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Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of loads of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating loads of injections, and customarily requiring co-selection methods.

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by loads of fold for longer edits. We describe troubleshooting methods that allow persistently excessive modifying efficiencies ensuing, as an illustration, in as lots as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the very best metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

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Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human)

4-PAC213Hu01
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1)

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse)

4-PAC213Mu01
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1)

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), PE

4-PAC213Hu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), PE

4-PAC213Mu01-PE
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC

4-PAC213Hu01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Cy3

4-PAC213Hu01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), HRP

4-PAC213Hu01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC

4-PAC213Mu01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Cy3

4-PAC213Mu01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), HRP

4-PAC213Mu01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), FITC

4-PAC213Hu01-FITC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), FITC

4-PAC213Mu01-FITC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Biotinylated

4-PAC213Hu01-Biotin
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Biotinylated

4-PAC213Mu01-Biotin
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC-Cy7

4-PAC213Hu01-APC-Cy7
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC213Mu01-APC-Cy7
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody

CAU22609-100ul 100ul
EUR 235.2

Vav 3 Oncogene (VAV3) Polyclonal Antibody

CAU22609-200ul 200ul
EUR 294

Vav 3 Oncogene (VAV3) Polyclonal Antibody

CAU22610-100ul 100ul
EUR 235.2

Vav 3 Oncogene (VAV3) Polyclonal Antibody

CAU22610-200ul 200ul
EUR 294

Vav 1 Oncogene (VAV1) Antibody

20-abx327434
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  • 100 ug
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Vav 1 Oncogene (VAV1) Antibody

20-abx327966
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  • 100 ug
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Vav 1 Oncogene (VAV1) Antibody

20-abx329103
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  • 100 ug
  • 50 ug

Vav 1 Oncogene (VAV1) Antibody

abx331549-100ul 100 ul
EUR 510

Vav 1 Oncogene (VAV1) Antibody

abx332110-100ul 100 ul
EUR 510

Vav 1 Oncogene (VAV1) Antibody

20-abx131502
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  • 100 ug
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Vav 1 Oncogene (VAV1) Antibody

20-abx128450
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  • 100 ug
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Vav 1 Oncogene (VAV1) Antibody

abx327434-100g 100 µg
EUR 250

Vav 1 Oncogene (VAV1) Antibody

abx327434-50g 50 µg
EUR 187.5

Vav 1 Oncogene (VAV1) Antibody

abx327966-100g 100 µg
EUR 250

Vav 1 Oncogene (VAV1) Antibody

abx327966-50g 50 µg
EUR 187.5

Vav 1 Oncogene (VAV1) Antibody

abx329103-100l 100 µl
EUR 187.5

Polyclonal Antibody to Vav 3 Oncogene (VAV3)

PAE929Hu01 100ul
EUR 245

Polyclonal Antibody to Vav 3 Oncogene (VAV3)

PAE929Hu02 100ul
EUR 245

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu02
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu02-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu01-Cy3
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu02-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu02-Cy3
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu02-HRP
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu01-FITC
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu02-FITC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu01-APC-Cy7
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu02-APC-Cy7
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu01-Biotin
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  • 100ul
  • 10ml
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu02-Biotin
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Recombinant Vav 1 Oncogene (VAV1)

RPU52395-100ug 100ug
EUR 523.6

Recombinant Vav 1 Oncogene (VAV1)

RPU52395-1mg 1mg
EUR 2320.5

Recombinant Vav 1 Oncogene (VAV1)

RPU52395-50ug 50ug
EUR 421.3

Recombinant Vav 1 Oncogene (VAV1)

RPU53092-100ug 100ug
EUR 542.3

Recombinant Vav 1 Oncogene (VAV1)

RPU53092-1mg 1mg
EUR 2402.4

Recombinant Vav 1 Oncogene (VAV1)

RPU53092-50ug 50ug
EUR 435.6

Recombinant Vav 1 Oncogene (VAV1)

RPC213Hu01 10ug
EUR 176

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Hu01
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  • 100 ug
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  • 50ug
  • 5 mg
Description: Recombinant Human Vav 1 Oncogene expressed in: E.coli

Recombinant Vav 1 Oncogene (VAV1)

RPC213Mu01 10ug
EUR 170

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Mu01
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  • 100 ug
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  • 5 mg
Description: Recombinant Mouse Vav 1 Oncogene expressed in: E.coli

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody

20-abx326674
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  • 100 ug
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Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx327138
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  • 100 ug
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Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx329104
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  • 100 ug
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Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-100ul 100 ul
EUR 560.4

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody

abx326674-100g 100 µg
EUR 250

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody

abx326674-50g 50 µg
EUR 187.5

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx327138-100g 100 µg
EUR 250

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx327138-50g 50 µg
EUR 187.5

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx329104-100l 100 µl
EUR 187.5

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-100g 100 µg Ask for price

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-20g 20 µg
EUR 412.5

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-50g 50 µg Ask for price

Rabbit VAV1 oncogene

E01A34867 96T
EUR 700
Description: ELISA

Mouse Vav 1 Oncogene (VAV1) Protein

20-abx168844
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

Human Vav 1 Oncogene (VAV1) Protein

20-abx167017
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

ELISA Kit for Vav 1 Oncogene (VAV1)

SEC213Hu 96Т
EUR 700

Human Vav 1 Oncogene (VAV1) ELISA Kit

EKU11988-48T 48T
EUR 555.66

Human Vav 1 Oncogene (VAV1) ELISA Kit

EKU11988-5x96T 5x96T
EUR 3770.55

Human Vav 1 Oncogene (VAV1) ELISA Kit

EKU11988-96T 96T
EUR 793.8

Human Vav 1 Oncogene (VAV1) ELISA Kit

EKN53099-48T 48T
EUR 345.73

Human Vav 1 Oncogene (VAV1) ELISA Kit

EKN53099-5x96T 5x96T
EUR 2346.03

Human Vav 1 Oncogene (VAV1) ELISA Kit

EKN53099-96T 96T
EUR 493.9

Human Vav 1 Oncogene(VAV1) ELISA Kit

QY-E04499 96T
EUR 433.2

Rabbit VAV1 oncogene ELISA kit

E04V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Vav 3 Oncogene (VAV3) Antibody

abx433439-200ul 200 ul
EUR 460.8

Vav 3 Oncogene (VAV3) Antibody

20-abx101251
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

Vav 3 Oncogene (VAV3) Antibody

20-abx101252
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

Vav 3 Oncogene (VAV3) Antibody

20-abx133365
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  • 100 ul
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  • 30 ul

Vav 3 Oncogene (VAV3) Antibody

abx101251-100l 100 µl
EUR 275

Vav 3 Oncogene (VAV3) Antibody

abx101251-1ml 1 ml
EUR 750

Vav 3 Oncogene (VAV3) Antibody

abx101251-200l 200 µl
EUR 337.5

Vav 3 Oncogene (VAV3) Antibody

abx101252-100l 100 µl
EUR 275

Vav 3 Oncogene (VAV3) Antibody

abx101252-1ml 1 ml
EUR 750

Vav 3 Oncogene (VAV3) Antibody

abx101252-200l 200 µl
EUR 337.5

Vav 3 Oncogene (VAV3) Antibody

abx433439-100g 100 µg
EUR 387.5

Vav1 (untagged) - Mouse vav 1 oncogene (Vav1), transcript variant 1, (10ug)

MC222049 10 µg Ask for price

Vav 1 Oncogene (VAV1) Magnetic Luminex Assay Kit

LKU601962-96T 96T
EUR 966

Human Proto- oncogene vav, VAV1 ELISA KIT

ELI-51387h 96 Tests
EUR 988.8

Mouse Proto- oncogene vav, Vav1 ELISA KIT

ELI-17706m 96 Tests
EUR 1038

Bovine Proto- oncogene vav, VAV1 ELISA KIT

ELI-51386b 96 Tests
EUR 1113.6

Vav1 (untagged) - Mouse vav 1 oncogene (Vav1), transcript variant 2, (10ug)

MC221867 10 µg Ask for price

Vav1 (untagged) - Mouse vav 1 oncogene (Vav1), transcript variant 3, (10ug)

MC220694 10 µg Ask for price

Vav1 (GFP-tagged) - Mouse vav 1 oncogene (Vav1) transcript variant 1, (10ug)

MG226846 10 µg Ask for price

Vav1 (Myc-DDK-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 1

MR226846 10 µg Ask for price

Vav1 (GFP-tagged) - Mouse vav 1 oncogene (Vav1) transcript variant 2, (10ug)

MG226847 10 µg Ask for price

Vav1 (Myc-DDK-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 3

MR210763 10 µg Ask for price

Vav1 (Myc-DDK-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 2

MR226847 10 µg Ask for price

Rabbit polyclonal antibody to VAV1 (vav 1 guanine nucleotide exchange factor)

TA308739 100 µl Ask for price

Vav1 Rabbit Polyclonal Antibody

ES3690-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Vav1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Vav1 Rabbit Polyclonal Antibody

ES3690-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Vav1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

VAV1 Rabbit Polyclonal Antibody

ES3771-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against VAV1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

VAV1 Rabbit Polyclonal Antibody

ES3771-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against VAV1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Oncogene TIM Rabbit Polyclonal Antibody

ES7597-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Oncogene TIM from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Oncogene TIM Rabbit Polyclonal Antibody

ES7597-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Oncogene TIM from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Rabbit Polyclonal Anti-FGFR1 Oncogene Partner Antibody

TA347379 100 µg Ask for price

Rabbit Polyclonal VAV1 Antibody

TA327850 100 µl Ask for price

Lenti ORF clone of Vav1 (mGFP-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 1

MR226846L4 10 µg Ask for price

KIT Oncogene (KIT) Rabbit anti-Human Polyclonal Antibody

GWB-E1C533 0.05 mg Ask for price

KIT Oncogene (KIT) Rabbit anti-Human Polyclonal Antibody

GWB-F29452 0.05 mg Ask for price

Vav Rabbit Polyclonal Antibody

ES7488-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Rabbit Polyclonal Antibody

ES7488-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Lenti ORF clone of Vav1 (mGFP-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 3

MR210763L4 10 µg Ask for price

Lenti ORF clone of Vav1 (mGFP-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 2

MR226847L4 10 µg Ask for price

Lenti ORF clone of Vav1 (Myc-DDK-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 1

MR226846L3 10 µg Ask for price

Rabbit Anti-Human VAV1 (aa 172-176) Polyclonal Antibody

CPB-1063RH 100 ul
EUR 552

Rabbit polyclonal FGFR1 Oncogene Partner antibody

TA311655 100 µl Ask for price

Rat VAV1 oncogene

E01A17405 96T
EUR 700
Description: ELISA

Goat VAV1 oncogene

E01A52301 96T
EUR 700
Description: ELISA

Lenti ORF clone of Vav1 (Myc-DDK-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 3

MR210763L3 10 µg Ask for price

Lenti ORF clone of Vav1 (Myc-DDK-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 2

MR226847L3 10 µg Ask for price

Rabbit Polyclonal antibody to PIM2 (pim-2 oncogene)

TA308697 100 µl Ask for price

Sheep VAV1 oncogene

E01A104595 96T
EUR 700
Description: ELISA

Mouse VAV1 oncogene

E01A26152 96T
EUR 700
Description: ELISA

Human VAV1 oncogene

E01A8662 96T
EUR 700
Description: ELISA

Vav 3 Oncogene Phospho-Tyr173 (VAV3 pY173) Antibody

20-abx325918
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  • 100 ug
  • 50 ug

Vav 3 Oncogene Phospho-Tyr173 (VAV3 pY173) Antibody

abx325918-100g 100 µg
EUR 250

Vav 3 Oncogene Phospho-Tyr173 (VAV3 pY173) Antibody

abx325918-50g 50 µg
EUR 187.5

Monkey VAV1 oncogene

E01A78448 96T
EUR 700
Description: ELISA

Canine VAV1 oncogene

E01A69731 96T
EUR 700
Description: ELISA

Bovine VAV1 oncogene

E01A87174 96T
EUR 700
Description: ELISA

VAV1 rabbit polyclonal antibody, Aff - Purified

AP20693PU-N 100 µg Ask for price

VAV1 rabbit polyclonal antibody, Aff - Purified

AP06359PU-N 100 µg Ask for price

VAV1 rabbit polyclonal antibody, Aff - Purified

AP02686PU-N 100 µg Ask for price

VAV1 rabbit polyclonal antibody, Aff - Purified

AP02686PU-S 50 µg Ask for price

Porcine VAV1 oncogene

E01A61019 96T
EUR 700
Description: ELISA

Chicken VAV1 oncogene

E01A95878 96T
EUR 700
Description: ELISA

Rabbit Polyclonal antibody to SET (SET nuclear oncogene)

TA308954 100 µl Ask for price

Fli-1 Oncogene (FLI1) Rabbit anti-Human Polyclonal (C-Terminus) Antibody

GWB-D12592 0.05 mg Ask for price

Rabbit polyclonal VAV1 (Ab-174) antibody

TA312892 100 µl Ask for price

Lenti ORF particles, Vav1 (GFP-tagged) - Mouse vav 1 oncogene (Vav1), transcript variant 1, 200ul, >10^7 TU/mL

MR226846L4V 200 µl Ask for price

Vav1 (phospho Tyr174) Rabbit Polyclonal Antibody

ES7486-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Vav1 (phospho Tyr174) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Vav1 (phospho Tyr174) Rabbit Polyclonal Antibody

ES7486-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Vav1 (phospho Tyr174) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Recombinant Vav 2 Oncogene (VAV2)

RPE928Hu01 10ug
EUR 160

Recombinant Vav 3 Oncogene (VAV3)

RPE929Hu01 10ug
EUR 320

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu01
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  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Recombinant Vav 3 Oncogene (VAV3)

RPE929Hu02 10ug
EUR 320

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu02
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Recombinant Vav 3 Oncogene (VAV3)

RPU44341-100ug 100ug
EUR 985.6

Recombinant Vav 3 Oncogene (VAV3)

RPU44341-1mg 1mg
EUR 4368

Recombinant Vav 3 Oncogene (VAV3)

RPU44341-50ug 50ug
EUR 792

Recombinant Vav 3 Oncogene (VAV3)

RPU44342-100ug 100ug
EUR 985.6

Recombinant Vav 3 Oncogene (VAV3)

RPU44342-1mg 1mg
EUR 4368

Recombinant Vav 3 Oncogene (VAV3)

RPU44342-50ug 50ug
EUR 792

Water-Pipe Smoking Publicity Deregulates a Set of Genes Related to Human Head and Neck Most cancers Growth and Prognosis

  • Water-pipe smoking (WPS) is popping into in all probability essentially the most well-liked type of tobacco use among the many many many youth, notably contained in the Coronary heart East, altering cigarettes quickly and turning into a essential danger of tobacco dependancy worldwide. Smoke from WPS accommodates comparable toxins as these current in cigarette smoke and is linked instantly with a variety of sorts of cancers together with lung and head and neck (HN) carcinomas.
  • Nonetheless, the underlying molecular pathways and/or objective genes accountable for the carcinogenic course of are nonetheless unknown. On this research, human frequent oral epithelial (HNOE) cells, NanoStringPanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain response (qRT-PCR) evaluation had been utilized to hunt out differentially expressed genes (DEG) modulated by WPS. In silico evaluation was carried out to analysis the have an effect on of those genes in HN most cancers affected explicit particular person’s biology and consequence. We discovered that WPS can induce the epithelial-mesenchymal transition (EMT: hallmark of most cancers development) of HNOE cells.
  • Additional considerably, our evaluation of NanoString revealed 23 genes deregulated beneath the have an effect on of WPS, accountable for the modulation of cell cycle, proliferation, migration/invasion, apoptosis, sign transduction, and inflammatory response. Further evaluation was carried out utilizing qRT-PCR of HNOE WPS-exposed and unexposed cells supported the reliability of our NanoString data.
  • Furthermore, we exhibit these DEG to be upregulated in most cancers in distinction with frequent tissue. Utilizing the Kaplan-Meier evaluation, we seen a big affiliation between WPS-deregulated genes and relapse-free survival/full survival in HN most cancers victims. Our findings level out that WPS can modulate EMT together with a set of genes which could possibly be instantly concerned in human HN carcinogenesis, thereby affecting HN most cancers victims’ survival.

A pilot research on the genetic range of Mycobacterium tuberculosis tough strains from tuberculosis victims contained in the Littoral house of Cameroon

Background: The re-emergence of tuberculosis (TB) worldwide, compounded by multi-drug resistance (MDR) of the causative brokers constitutes a big concern to the administration of the illness. Speedy analysis and correct stress identification are pivotal to the administration of the illness. This pilot research investigated the genetic range of Mycobacterium tuberculosis tough (MTBC) strains from TB victims contained in the Littoral house of Cameroon together with their resistance to rifampicin (RIF).

Victims and methods: This was a cross sectional hospital-based research carried out between January and December 2017 and together with 158 isolates from sputum smear constructive of us [105 (66.5%) males and 53 (33.5%) females]. Sputum samples had been examined utilizing Xpert MTB/RIF, adopted by customized on Lowenstein-Jensen medium. Isolates had been additional subjected to molecular characterization utilizing IS6110 typing, deletion evaluation and spoligotyping.

Outcomes: 13 (8.8%) of the 147 isolates with susceptibility outcomes accessible had been proof in the direction of RIF. Drug resistance occurred in 5/50 (10%) feminine in contrast with 8/97 (8.2%) male (OR, 0.81; 0.25-2.62; p = 0.764), and there was no essential distinction all by way of the age ranges (p = 0.448). Nonetheless, RIF resistance was related (OR, 0.18, 95%CI, 0.05-0.69; p = 0.023) with beforehand handled victims [(4/14 (28.6%)] in contrast with new ones [9/133 (6.8%)].

The 150 acknowledged lineages included amongst others 54 (36%) Cameroon, 18 (12%) UgandaI, 32 (21.3%) Haarlem, 17 (11.3%) Ghana, 9(6%) West African 1, 7(4.7%) Delhi/CAS, 4 (2.7%) LAM and three (2%) UgandaII. Of the 150 isolates, a really highly effective cluster was the Cameroon SIT 61, with 43(28.7%) isolates. Six (35.3%) of the 17 UgandaI sub-lineage had been RIF resistant (OR, 9.58; 95%CI, 2.74-33.55, p = 0.001).

Conclusion: The cosmopolitan Littoral house presents with an enormous Mycobacterium tuberculosis (MTB) strains range and the UgandaI sub-lineage attainable related to RIF resistance. Understanding the unfold of this clade by way of surveillance will improve TB administration contained in the house.

Prediction of Clearance of Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins in Youngsters: Utility of Allometric Scaling 

Allometric scaling can be utilized for the extrapolation of pharmacokinetic parameters from adults to kids. The target of this research was to foretell clearance of therapeutic proteins (monoclonal and polyclonal antibodies and non-antibody proteins) allometrically in preterm neonates to adolescents. There have been 13 monoclonal antibodies, seven polyclonal antibodies, and 9 therapeutic proteins (non-antibodies) within the research.

The clearance of therapeutic proteins was predicted utilizing the age dependent exponents (ADE) mannequin after which in contrast with the noticed clearance values. There have been in whole 29 therapeutic proteins on this research with 75 observations. The variety of observations with ≤30%, ≤50%, and >50% prediction error was 60 (80%), 72 (96%), and three (4%), respectively.

General, the anticipated clearance values of therapeutic proteins in kids was good. The allometric technique proposed on this manuscript can be utilized to pick out first-in-pediatric dose of therapeutic proteins in pediatric scientific trials.

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