DNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

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agresearchforum

Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of loads of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating loads of injections, and customarily requiring co-selection methods.

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by loads of fold for longer edits. We describe troubleshooting methods that allow persistently excessive modifying efficiencies ensuing, as an illustration, in as lots as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the very best metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

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Vav 1 Oncogene (VAV1) Antibody

20-abx329103
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human)

4-PAC213Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1)

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse)

4-PAC213Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1)

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Hu01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 1 Oncogene expressed in: E.coli

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Mu01
  • EUR 480.80
  • EUR 232.00
  • EUR 1528.00
  • EUR 576.00
  • EUR 1052.00
  • EUR 385.00
  • EUR 3670.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Vav 1 Oncogene expressed in: E.coli

Proto-Oncogene Vav (VAV1) Antibody

abx011903-100ug 100 ug
EUR 411

Proto-Oncogene Vav (VAV1) Antibody

20-abx012888
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Proto-Oncogene Vav (VAV1) Antibody

20-abx000854
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

Proto-Oncogene Vav (VAV1) Antibody

abx239377-100ug 100 ug
EUR 551

Proto-Oncogene Vav (VAV1) Antibody

20-abx141277
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC

4-PAC213Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Biotinylated

4-PAC213Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Cy3

4-PAC213Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), FITC

4-PAC213Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), HRP

4-PAC213Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), PE

4-PAC213Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC

4-PAC213Mu01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Biotinylated

4-PAC213Mu01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Cy3

4-PAC213Mu01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), FITC

4-PAC213Mu01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), HRP

4-PAC213Mu01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), PE

4-PAC213Mu01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Mouse Vav 1 Oncogene (VAV1) Protein

20-abx168844
  • EUR 676.00
  • EUR 272.00
  • EUR 2054.00
  • EUR 801.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Vav 1 Oncogene (VAV1) Protein

20-abx167017
  • EUR 690.00
  • EUR 286.00
  • EUR 2124.00
  • EUR 815.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Proto-Oncogene Vav (VAV1) Protein

20-abx263391
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
  • 100 ug
  • 10 ug
  • 2 µg

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC-Cy7

4-PAC213Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC213Mu01-APC-Cy7
  • EUR 583.00
  • EUR 6610.00
  • EUR 1750.00
  • EUR 778.00
  • EUR 324.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Human Vav 1 Oncogene(VAV1) ELISA Kit

QY-E04499 96T
EUR 361

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-100ul 100 ul
EUR 467

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody

20-abx326674
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx327138
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx329104
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Proto-Oncogene Vav (VAV1) ELISA Kit

abx595617-96tests 96 tests
EUR 637

Human Proto-oncogene vav (VAV1) ELISA Kit

abx384219-96tests 96 tests
EUR 911

Bovine Proto- oncogene vav, VAV1 ELISA KIT

ELI-51386b 96 Tests
EUR 928

Human Proto- oncogene vav, VAV1 ELISA KIT

ELI-51387h 96 Tests
EUR 824

Mouse Proto- oncogene vav, Vav1 ELISA KIT

ELI-17706m 96 Tests
EUR 865

Proto-Oncogene Vav Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx012571
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-VAV1 Antibody

A00691-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for VAV1 Antibody (VAV1) detection. Tested with WB in Human, Mouse, Rat.

Rabbit VAV1 oncogene ELISA kit

E04V0079-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu02
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Antibody

20-abx133365
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Vav 3 Oncogene (VAV3) Antibody

20-abx101251
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Vav 3 Oncogene (VAV3) Antibody

20-abx101252
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Vav 3 Oncogene (VAV3) Antibody

abx433439-200ul 200 ul
EUR 384

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu02-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu02-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu02-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu02-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu02-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu02-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Anti-Vav antibody

STJ96227 200 µl
EUR 197
Description: Rabbit polyclonal to Vav.

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu01
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • EUR 996.00
  • EUR 1892.00
  • EUR 610.00
  • EUR 6820.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu02
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • EUR 996.00
  • EUR 1892.00
  • EUR 610.00
  • EUR 6820.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Vav Polyclonal Antibody

ES7488-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody

ES7488-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody

ABP56489-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ABP56489-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ABP56489-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Rabbit Anti-Human Vav1 Polyclonal Antibody, Phospho-Tyr174

CPB-700RH 100 ul
EUR 559

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu02-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Anti-VAV1 Antibody

A30436 100ul
EUR 397
Description: Rabbit Polyclonal VAV1 Antibody. Validated in ELISA, IF and tested in Human, Mouse, Rat.

Anti-VAV1 antibody

STJ11100612 50 µl
EUR 287
Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Anti-Vav1 antibody

STJ96228 200 µl
EUR 197
Description: Rabbit polyclonal to Vav1.

Anti-VAV1 antibody

STJ96406 200 µl
EUR 197
Description: Rabbit polyclonal to VAV1.

Anti-VAV1 antibody

STJ117302 100 µl
EUR 277
Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

anti- VAV1 antibody

FNab09377 100µg
EUR 585
Description: Antibody raised against VAV1

Anti-VAV1 antibody

PAab09377 100 ug
EUR 412

VAV1 Vav 1 Guanine Nucleotide Exchange Factor Human Recombinant Protein

PROTP15498 Regular: 10ug
EUR 317
Description: VAV1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (189-565a.a) and having a molecular mass of 46.8kDa.

Pig VAV1 oncogene ELISA kit

E07V0079-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig VAV1 oncogene ELISA kit

E07V0079-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig VAV1 oncogene ELISA kit

E07V0079-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog VAV1 oncogene ELISA kit

E08V0079-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Canine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog VAV1 oncogene ELISA kit

E08V0079-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Canine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog VAV1 oncogene ELISA kit

E08V0079-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat VAV1 oncogene ELISA kit

E06V0079-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat VAV1 oncogene ELISA kit

E06V0079-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat VAV1 oncogene ELISA kit

E06V0079-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human VAV1 oncogene ELISA kit

E01V0079-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human VAV1 oncogene ELISA kit

E01V0079-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Human VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human VAV1 oncogene ELISA kit

E01V0079-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Human VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse VAV1 oncogene ELISA kit

E03V0079-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Water-Pipe Smoking Publicity Deregulates a Set of Genes Related to Human Head and Neck Most cancers Growth and Prognosis

  • Water-pipe smoking (WPS) is popping into in all probability essentially the most well-liked type of tobacco use among the many many many youth, notably contained in the Coronary heart East, altering cigarettes quickly and turning into a essential danger of tobacco dependancy worldwide. Smoke from WPS accommodates comparable toxins as these current in cigarette smoke and is linked instantly with a variety of sorts of cancers together with lung and head and neck (HN) carcinomas.
  • Nonetheless, the underlying molecular pathways and/or objective genes accountable for the carcinogenic course of are nonetheless unknown. On this research, human frequent oral epithelial (HNOE) cells, NanoStringPanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain response (qRT-PCR) evaluation had been utilized to hunt out differentially expressed genes (DEG) modulated by WPS. In silico evaluation was carried out to analysis the have an effect on of those genes in HN most cancers affected explicit particular person’s biology and consequence. We discovered that WPS can induce the epithelial-mesenchymal transition (EMT: hallmark of most cancers development) of HNOE cells.
  • Additional considerably, our evaluation of NanoString revealed 23 genes deregulated beneath the have an effect on of WPS, accountable for the modulation of cell cycle, proliferation, migration/invasion, apoptosis, sign transduction, and inflammatory response. Further evaluation was carried out utilizing qRT-PCR of HNOE WPS-exposed and unexposed cells supported the reliability of our NanoString data.
  • Furthermore, we exhibit these DEG to be upregulated in most cancers in distinction with frequent tissue. Utilizing the Kaplan-Meier evaluation, we seen a big affiliation between WPS-deregulated genes and relapse-free survival/full survival in HN most cancers victims. Our findings level out that WPS can modulate EMT together with a set of genes which could possibly be instantly concerned in human HN carcinogenesis, thereby affecting HN most cancers victims’ survival.

A pilot research on the genetic range of Mycobacterium tuberculosis tough strains from tuberculosis victims contained in the Littoral house of Cameroon

Background: The re-emergence of tuberculosis (TB) worldwide, compounded by multi-drug resistance (MDR) of the causative brokers constitutes a big concern to the administration of the illness. Speedy analysis and correct stress identification are pivotal to the administration of the illness. This pilot research investigated the genetic range of Mycobacterium tuberculosis tough (MTBC) strains from TB victims contained in the Littoral house of Cameroon together with their resistance to rifampicin (RIF).

Victims and methods: This was a cross sectional hospital-based research carried out between January and December 2017 and together with 158 isolates from sputum smear constructive of us [105 (66.5%) males and 53 (33.5%) females]. Sputum samples had been examined utilizing Xpert MTB/RIF, adopted by customized on Lowenstein-Jensen medium. Isolates had been additional subjected to molecular characterization utilizing IS6110 typing, deletion evaluation and spoligotyping.

Outcomes: 13 (8.8%) of the 147 isolates with susceptibility outcomes accessible had been proof in the direction of RIF. Drug resistance occurred in 5/50 (10%) feminine in contrast with 8/97 (8.2%) male (OR, 0.81; 0.25-2.62; p = 0.764), and there was no essential distinction all by way of the age ranges (p = 0.448). Nonetheless, RIF resistance was related (OR, 0.18, 95%CI, 0.05-0.69; p = 0.023) with beforehand handled victims [(4/14 (28.6%)] in contrast with new ones [9/133 (6.8%)].

The 150 acknowledged lineages included amongst others 54 (36%) Cameroon, 18 (12%) UgandaI, 32 (21.3%) Haarlem, 17 (11.3%) Ghana, 9(6%) West African 1, 7(4.7%) Delhi/CAS, 4 (2.7%) LAM and three (2%) UgandaII. Of the 150 isolates, a really highly effective cluster was the Cameroon SIT 61, with 43(28.7%) isolates. Six (35.3%) of the 17 UgandaI sub-lineage had been RIF resistant (OR, 9.58; 95%CI, 2.74-33.55, p = 0.001).

Conclusion: The cosmopolitan Littoral house presents with an enormous Mycobacterium tuberculosis (MTB) strains range and the UgandaI sub-lineage attainable related to RIF resistance. Understanding the unfold of this clade by way of surveillance will improve TB administration contained in the house.

Prediction of Clearance of Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins in Youngsters: Utility of Allometric Scaling 

Allometric scaling can be utilized for the extrapolation of pharmacokinetic parameters from adults to kids. The target of this research was to foretell clearance of therapeutic proteins (monoclonal and polyclonal antibodies and non-antibody proteins) allometrically in preterm neonates to adolescents. There have been 13 monoclonal antibodies, seven polyclonal antibodies, and 9 therapeutic proteins (non-antibodies) within the research.

The clearance of therapeutic proteins was predicted utilizing the age dependent exponents (ADE) mannequin after which in contrast with the noticed clearance values. There have been in whole 29 therapeutic proteins on this research with 75 observations. The variety of observations with ≤30%, ≤50%, and >50% prediction error was 60 (80%), 72 (96%), and three (4%), respectively.

General, the anticipated clearance values of therapeutic proteins in kids was good. The allometric technique proposed on this manuscript can be utilized to pick out first-in-pediatric dose of therapeutic proteins in pediatric scientific trials.

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